The Pennsylvania Railroad ended up using the greatest number (598) of 2-10-0 locomotives. They were quite successfully used on the PRR Allegheny Mountain routes.
Because of the lack of a rear truck, the 2-10-0 wheel arrangement meant that the firebox be place between the drives making it very narrow or on top of the drivers making it very high and shallow also limiting the driver diameter. As a result, these locomotives could only be used for slow drag service.
| No. | Class | F.M. Whyte | Gauge | Railroad Line | Location | Status | Builder Information | Notes |
|---|---|---|---|---|---|---|---|---|
| 203 (402) | D-2 | 2-10-0 | 4'-8½" | GM (AT&N) | display | Baldwin | | |
| 209 (533) | D-2 | 2-10-0 | 4'-8½" | GM (SAL) | display | Baldwin #61233, 1930 | | |
| 208 (530) | D-2 | 2-10-0 | 4'-8½" | GM (SAL) | display | | ||
| 1630 | Russian | 2-10-0 | 4'-8½" | SLSF | out of service | Baldwin #47953, 1918 | ||
| 1632 | Russian | 2-10-0 | 4'-8½" | SLSF (SR) | cosmetic restoration | Baldwin #48522, 1918 | ||
| 1621 | Russian | 2-10-0 | 4'-8½" | SLSF | display | Baldwin #48420, 1918 | | |
| 544 (206) | Russian | 2-10-0 | 4'-8½" | SAL (GM) | display | ALCO (Brooks) #58902, 1918 | | |
| 4483 | I1sa | 2-10-0 | 4'-8½" | PRR | display | Baldwin #56534, 1923 | | |
| 1615 | Russian | 2-10-0 | 4'-8½" | SLSF | display | Baldwin #58829, 1917 | | |
| 90 | BLWl | 2-10-0 | 4'-8½" | GWR | operational | Baldwin #57812, 1924 | ||
| 1625 | Russian | 2-10-0 | 4'-8½" | SLSF | display | ALCO (Schenectady) #58903, 1918 | | |
| 950 (113) | G | 2-10-0 | 4'-8½" | MSP&SSM (Buffalo & Susquehanna) | display | Baldwin #17914, 1900 | ||
| 41 (401) | BLWl | 2-10-0 | 4'-8½" | Woodward Iron (AT&N) | display | Baldwin #60341, 1928 |